Left ventricular function in hemorrhagic shock and after Hextend® resuscitation in anesthetized hamster

Abstract

Left ventricular function during moderate hemorrhagic shock and after resuscitation was studied using a miniature pressure‐volume conductance catheter in an anesthetized hamster model. Moderate hemorrhagic shock was induced by 40% blood volume withdrawal in 15 minutes. A single volume of Hextend®, a comparatively higher viscosity plasma expander, was infused after 30 min of hemorrhagic shock. Cardiac function‐related parameters were measured and derived. Volume filling rate, a load dependent parameter, and a load independent parameter negative pressure‐time derivative (dP/dtmin) were used to assess the diastolic function. Systolic function was assessed by the peak positive pressure‐time derivative (dP/dtmax) and maximum ventricular power divided by square of end‐diastolic volume. Preliminary results showed that volume filling rate was restored to 95 ± 16% of baseline 30 min after resuscitation, this being 15 ‐ 20% greater than during shock (p<0.05). dP/dtmin recovered from 53 ± 15% of baseline during shock to 67 ± 20% of baseline 30 min after resuscitation. dP/dtmax improved from 75 ± 16% of baseline during shock to 94 ± 24% of baseline after resuscitation. It is concluded that Hextend® improved both systolic and diastolic function after moderate hemorrhagic shock in the early stage of resuscitation.