Abstract
Determinants of isovolumic relaxation period (IRP) and diastolic peak filling rate (PFR) were studied in 75 patients with systemic hypertension, using radionuclide angiography and echocardiography. Patients with left ventricular (LV) hypertrophy (LV mass index ≥134 g/m^2 for men and ≥110 g/m^2 for women) had prolonged IRP and time to PFR, and reduced PFR when compared to hypertensives without LV hypertrophy. Patients with concentric (relative diastolic wall thickness ≥0.45) and eccentric LV hypertrophy had depressed indexes of diastolic function when compared to hypertensives without LV hypertrophy. Multiple regression analysis showed that LV hypertrophy, time to end-systole, and age were the only determinants of IRP. PFR was found to be influenced by LV mass index, ejection fraction (EF), age, and by heart rate. Only 31 and 40% of the variance of IRP and PFR, respectively, were explained by the considered variables, however. This suggests that other factors (such as filling pressure and intrinsic relaxation properties) play a major role in influencing diastolic function in patients with systemic hypertension.
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