Abstract
BackgroundNew-onset atrial fibrillation (NOAF) occurs frequently in patients with acute myocardial infarction (AMI), and is associated with increased subsequent cardiovascular mortality. However, only a few studies directly evaluated the relationship of left ventricular ejection fraction (LVEF) or left atrium diameter (LAD) and NOAF following AMI.Materials and MethodsMEDLINE®, EMBASE® and the Cochrane Library were carried out to find studies until January 2017. Pooled mean difference (MD) and 95% confidence interval (CI) were calculated to evaluate the value of LVEF and LAD in the prediction of NOAF after AMI. We performed sensitivity analyses to explore the potential sources of heterogeneity. Statistical analyses were carried out using the Revman 5.3.ResultWe included 10 qualifying studies comprising a total of 708 patients with NOAF and 6785 controls. Overall, decreased LVEF and increased LAD levels had a significant positive association with NOAF in patients with AMI. The MD in the LVEF levels between the patients with and those without NOAF was −4.91 units (95% Cl: −5.70 to −4.12), test for overall effect z-score = 12.18 (p < 0.00001, I2 = 35%). Moreover, in a subgroup analysis, the MD for LAD and NOAF was 2.55 units (95% Cl: 1.91 to 3.19), test for overall effect z-score = 7.80 (p < 0.00001, I2 = 57%).ConclusionsOur meta-analysis demonstrated that both decreased LVEF and increased LAD levels were associated with greater risk of NOAF following AMI.
Highlights
Atrial fibrillation (AF) occurs commonly in hospitalized patients with acute myocardial infarction (AMI), with a reported incidence between 2% and 20% [1], and is closely associated with prolonged hospitalization, increased subsequent cardiovascular mortality in AMI patients [2,3,4,5,6]
Only a few studies directly evaluated the relationship of left ventricular ejection fraction (LVEF) or left atrium diameter (LAD) and New-onset atrial fibrillation (NOAF) following AMI
Our meta-analysis demonstrated that both decreased LVEF and increased LAD levels were associated with greater risk of NOAF following AMI
Summary
Atrial fibrillation (AF) occurs commonly in hospitalized patients with acute myocardial infarction (AMI), with a reported incidence between 2% and 20% [1], and is closely associated with prolonged hospitalization, increased subsequent cardiovascular mortality in AMI patients [2,3,4,5,6]. To our knowledge, only a few studies directly evaluated the associations between LVEF or LAD and newonset AF (NOAF) in patients with AMI We conducted this comprehensive meta-analysis to explore the impact of LVEF on NOAF following AMI by collecting data for previously published studies. Only a few studies directly evaluated the relationship of left ventricular ejection fraction (LVEF) or left atrium diameter (LAD) and NOAF following AMI
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
