Abstract
Methods Cardiac magnetic resonance (CMR) was performed at 3.0 Tesla in 109 asymptomatic ToF patients, (age 19.3 ±12.8 years) after surgical correction (16.6±10.0 years post operation), and 64 age-matched controls. Parameters of LV and left atrial (LA) function and aortic distensibility were obtained from cine CMR. In a subgroup (n=50), T1 mapping was used to determine the myocardial extracellular volume fraction (ECV) as an index of diffuse myocardial fibrosis.
Highlights
Repair of tetralogy of Fallot (ToF) frequently has longterm sequelae of right ventricle (RV) dysfunction, which may lead to left ventricular (LV) dysfunction due to unfavorable RV coupling
We hypothesized that ToF can lead to adverse left heart remodeling, including LV myocardial extracellular matrix expansion, hallmarks of a cardiomyopathic process
Parameters of LV and left atrial (LA) function and aortic distensibility were obtained from cine Cardiac magnetic resonance (CMR)
Summary
Adverse myocardial and aortic remodeling in patients with tetralogy of Fallot without symptoms of heart failure after surgical repair. Ana C Andrade1*, Michael Jerosch-Herold, Inga Voges, Minh H Pham, Ravi V Shah, Christopher Hart, Philip Wegner, Hans-Heiner Kramer, Carsten Rickers
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
