Abstract
Nineteen bipolar inpatients in manic episodes and 19 normal control subjects were tested on a two-button task which required turning (swiveling) 180° to collect coin-reinforcers. Significantly more right-handed ( 8 16 ) manic patients turned left (consistently 16 times to collect reinforcement) than right-handed normal controls ( 1 15 ), most of whom turned consistently right 16 times. Right-handed manic patients were also significantly slower with both hands on a motor sequencing task (Pin Test) than the normal controls. Left hemi-spatial preference may be linked to asymmetric striatal dopaminergic activity common to all psychoses.
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