Left temporal pole contributes to creative thinking via an individual semantic network.

Abstract

The neural substrates that contribute to creative thinking through the recruitment of semantic memory structures remain largely unknown. This study sought to investigate the properties of semantic networks using a semantic judgment rating task at the individual level and explore the relationship among creative abilities, the topological properties of semantic networks, and their underlying brain structures. We first used a semantic judgment rating to assess individual semantic networks and computed their topological properties. The analysis confirmed a significant correlation between the creative thinking abilities assessed by an alternate uses task and all three topological properties. In addition, voxel-based morphometry was employed to assess the neural correlates of gray matter volume (GMV) related to different topological properties of the semantic network. Results revealed a positive correlation between global efficiency and the left temporal pole cortex, considered to be involved in semantic information transmission and processing. Furthermore, mediation analysis found that the global efficiency of the individual semantic network mediated the association between the left temporal pole GMV and creative thinking, showing that the relationship between left temporal pole GMV and creative thinking may be affected by the semantic networks. To the best of our knowledge, this study is the first to combine a behavioral investigation of semantic networks with magnetic resonance imaging to shed light on the cerebral structural basis of semantic memory networks, in addition to their relationship to creativity.