Abstract
Background The cardiovascular MRI late gadolinium enhancement (LGE) sequence has developed as a tool to evaluate fibrosis in the atrial walls. LA remodelling and fibrosis is theorized to precede the onset of and to increase with the persistence of AF. Pathological studies have demonstrated that other cardiac diseases are associated with LA fibrosis regardless of the presence of AF. Identifying conditions associated with LA LGE in the general population could be important for risk stratification of atrial fibrosis and AF development in patients with such comorbidities. This study aims to identify common clinical conditions associated with greater LA LGE.
Highlights
The cardiovascular MRI late gadolinium enhancement (LGE) sequence has developed as a tool to evaluate fibrosis in the atrial walls
LA LGE was associated with LA end diastolic volume (LAEDV) index in subjects both with and without AF (r2= 0.192, r2= 0.226 respectively, p
LA ejection fraction (EF) showed an association with LA LGE
Summary
The cardiovascular MRI late gadolinium enhancement (LGE) sequence has developed as a tool to evaluate fibrosis in the atrial walls. LA remodelling and fibrosis is theorized to precede the onset of and to increase with the persistence of AF. Pathological studies have demonstrated that other cardiac diseases are associated with LA fibrosis regardless of the presence of AF. Identifying conditions associated with LA LGE in the general population could be important for risk stratification of atrial fibrosis and AF development in patients with such comorbidities. This study aims to identify common clinical conditions associated with greater LA LGE. Analyzed using linear regression, t-tests, and analysis of covariance using JMP v10 (SAS Institute Cary NC)
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