Abstract
Introduction: It is well established that atrial fibrillation (AF) is associated with the risk of thromboembolic events. Furthermore, in the first 2 weeks following termination of AF by percutaneous left atrial radiofrequency ablation (LARFA) this risk in dramatically increased despite continuous anticoagulant therapy. However, limit data are available for the roleplatelets play in this increased thrombotic risk.Therefore, this studywasdesigned to investigate the effect of LARFA on platelet reactivity within the left and right atria. Methods: Blood samples were obtained from the left atria, the right atria and the femoral vein in eightpatients undergoing elective pulmonary vein isolation at the start of the procedure (afterheparinadministration) and immediately prior to catheter removal at the end of the procedure. Unstimulated blood samples were incubated with the platelet specific antibodies against glycoprotein IIb/IIIa, p b R t L ( s L C i s w b
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