Left atrial appendage peak flow velocity predicts improvement in mitral regurgitation after atrial fibrillation ablation

Abstract

BackgroundMitral regurgitation (MR) is associated with an increased risk of developing atrial fibrillation (AF) and high AF recurrence ratio after ablation. Left atrial appendage (LAA) is involved in left atrium (LA) pressure modulation and LAA peak flow velocity (LAAV) is validated as an indicator of LA contractile and reservoir function. LA function is related to the MR pathology, but the relationship between LAAV and improvement in MR after ablation remains unknown. MethodsThe present study included AF patients with moderate or severe MR from the Osaka Rosai Atrial Fibrillation ablation (ORAF) registry. We evaluated MR severity one-year post-ablation and assigned the patients based on MR improvement (at least a one-grade improvement in MR over one year) and investigated the impact of the relevant factors, including LAAV, on MR improvement. ResultsThis study population included a total of 289 patients [paroxysmal AF (PAF), 112 patients; persistent AF (PerAF), 177 patients]. Kaplan-Meier analysis demonstrated that the patients with MR improvement had a significantly lower risk of late arrhythmia recurrence than those without (log-rank p < 0.001). MR improvement was observed in 56.3 % (63/112) of PAF patients and 55.4 % (98/177) of PerAF patients. Multiple regression analysis showed that LAAV was an independent and significant determinant of MR improvement post-ablation in both PAF and PerAF patients (p = 0.037 and p = 0.018, respectively), in addition to age and hemoglobin in PerAF patients (p = 0.045 and p = 0.048, respectively). ConclusionLAAV can predict an improvement in MR after catheter ablation in both PAF and PerAF patients.