Left Atrial Appendage Morphology and Left Atrial Wall Thickness Are Associated with Cardio-Embolic Stroke.

Agne Adukauskaite,Thomas Senoner,Axel Bauer,Silvana Mueller,Florian Hintringer,Christian Boehme,Fabian Barbieri,Fabian Plank,Wolfgang Dichtl,Gudrun Feuchtner,Michael Knoflach

doi:10.3390/jcm9123944

Agne Adukauskaite, Thomas Senoner + Show 9 more

Open Access

https://doi.org/10.3390/jcm9123944

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Abstract

Background. New markers for stroke risk stratification in patients with atrial fibrillation (AF) are on demand. Hence, we aimed to investigate the association of left atrial appendage (LAA) and left atrium (LA) morphological parameters in patients with cardio-embolic (CE) stroke due to AF in comparison to controls without stroke. Methods: A retrospective analysis of cardiac computed tomography angiography (CTA) examinations performed between 2006 and 2017 for clinical indications in 158 patients (median age 65 (54–73) years, 48.7% females) was conducted: 56 patients with CE stroke were compared to 102 controls not differing in gender, body mass index (BMI) and CHA2DS2-VASc score. Results: On multivariable regression analysis adjusted for CHA2DS2-VASc score and LA diameter CE stroke was independently associated with the following parameters: windsock LAA type (OR 2.55; CI: 1.04–6.26, p = 0.041), a greater lobe number (OR 1.54; CI: 1.13–2.10, p = 0.006), a greater LAA ostium area (OR 1.88; CI: 1.38–2.55, p < 0.001) and a greater left atrium wall thickness (LAWT) in the middle and right part, measured along the anterior LA wall in the axial plane (respectively, OR 1.94; CI: 1.26–3.0, p = 0.003 and OR 1.57; CI: 1.07–2.31, p = 0.021). Conclusions: The windsock LAA type, a greater LAA lobe number, a larger LAA ostium and a greater LAWT are associated with CE stroke. These CTA parameters could improve risk stratification for thromboembolic stroke.

Highlights

Stroke is one of the leading causes of functional impairment, morbidity, mortality, and socioeconomic burden worldwide [1]
We show that only the windsock left atrial appendage (LAA) type is independently associated with CE stroke in the presence of atrial fibrillation (AF)
According to his study, patients with a windsock type were 4.5 times more likely to have had a stroke/transient ischemia attack (TIA) (p = 0.038) in comparison to patients with chicken-wing [8]. This has been confirmed by a meta-analysis of Lupercio et al, showing that AF patients with a chicken-wing LAA type have lower risk to suffer from thromboembolism as compared to AF patients with a non-chicken-wing type [14]

Summary

Introduction

Stroke is one of the leading causes of functional impairment, morbidity, mortality, and socioeconomic burden worldwide [1]. Results: On multivariable regression analysis adjusted for CHA2DS2-VASc score and LA diameter CE stroke was independently associated with the following parameters: windsock LAA type (OR 2.55; CI: 1.04–6.26, p = 0.041), a greater lobe number (OR 1.54; CI: 1.13–2.10, p = 0.006), a greater LAA ostium area (OR 1.88; CI: 1.38–2.55, p < 0.001) and a greater left atrium wall thickness (LAWT) in the middle and right part, measured along the anterior LA wall in the axial plane (respectively, OR 1.94; CI: 1.26–3.0, p = 0.003 and OR 1.57; CI: 1.07–2.31, p = 0.021). Conclusions: The windsock LAA type, a greater LAA lobe number, a larger LAA ostium and a greater LAWT are associated with CE stroke These CTA parameters could improve risk stratification for thromboembolic stroke

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