Abstract
Objective In patients with non-valvular atrial fibrillation, embolic stroke is thought to be associated with left atrial appendage (LAA)thrombi.We assessed the efficacy and safety of percutaneous closure of the LAA for prevention of stroke in patients with atrial fibrillation. Methods Adult patients with non-valvular atrial fibrillation and CHADS2 score ≥1 were eligible for inclusion from March 2014 to March 2016.Patients enrolled were undergone percutaneous left atrial appendage closure, and followed up with echocardiogram at 1, 3, 6 and 12 months after procedure.Efficacy was assessed by a primary composite endpoint of stroke, cardiovascular death, and systemic embolism.Serious adverse events that constituted the primary endpoint for safety included major bleeding, pericardial effusion, and device embolization. Results Thirty patients were enrolled for left atrial appendage closure.Three patients quit the study.At the follow-up of 190 patient-months(6.3 months), Efficacy end point happened with 0 per 100 patient-months.Safety end point happened with 0.5/100 patient-months. Conclusion percutaneous left atrial appendage closure was an effective and safe method for the prevention of stroke in atrial fibrillation patients. Key words: Atrial fibrillation; Left atrial appendage closure
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