Abstract
Crataeva tapia is a plant popularly used for diabetes treatment, in Brazil. Progressive decline in renal and hepatic functions has been described in patients with diabetes mellitus, and mortality rate is increased in patients with chronic liver and renal disease. This study aimed to evaluate whether Crataeva tapia bark lectin (CrataBL) improves hyperglycemia and renal and hepatic damage in diabetic mice. CrataBL was purified by ion exchange chromatography on CM-cellulose, and intraperitoneal administration of CrataBL to alloxan-induced diabetic mice at dose of 10 mg/Kg/day and 20 mg/Kg/day for 10 days significantly reduced serum glucose levels by 14.9% and 55.9%, respectively. Serum urea, creatinine, aspartate aminotransferase, and alanine aminotransferase were also significantly reduced after treatment with both doses of CrataBL. Furthermore, histological analysis of liver, kidney, and pancreas revealed an improvement in the tissue morphology upon treatment with CrataBL. The results suggest that CrataBL has a beneficial hypoglycemic activity and improves the renal and hepatic complications of diabetes. Therefore, this lectin may be a promising agent for the treatment of diabetes, and this might be the basis for its use in the folk medicine as an alternative treatment to manage diabetes-related complications such as hyperglycemia and tissue damage.
Highlights
IntroductionCrataeva tapia ( known as Crateva tapia), a plant ofCapparidaceae family, is commonly found in Pluvial Tropical Atlantic Forest and Pantanal Tropical Forest in Brazil [1]
Crataeva tapia, a plant ofCapparidaceae family, is commonly found in Pluvial Tropical Atlantic Forest and Pantanal Tropical Forest in Brazil [1]
In this study the mice subjected to alloxan injection showed symptoms of severe diabetes such as hyperglycemia
Summary
Crataeva tapia ( known as Crateva tapia), a plant ofCapparidaceae family, is commonly found in Pluvial Tropical Atlantic Forest and Pantanal Tropical Forest in Brazil [1]. C. tapia is known by Northeast Brazilian people as “paudalho” or “tapia” and its bark is largely used in the folk medicine for the treatment of diabetes. A lectin with a molecular weight of 40 kDa (CrataBL) was purified from the aqueous extract of Crataeva tapia bark [2]. Several plant lectins have been demonstrated to possess a variety of biological activities including antitumor [4,5,6], anti-inflammatory [7, 8], antimicrobial [9,10,11], analgesic [4], antioxidant [3] insecticidal [2, 12,13,14], anticoagulant [15], and hypoglycemic [16, 17].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Evidence-Based Complementary and Alternative Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
