Abstract
Hydroxyapatite Ca10(PO4)6(OH)2 nanoparticles have been successfully synthesized by the wet chemical precipitation method at 60 °C in the presence of biocompatible natural surfactant—lecithin. The composition and morphology of nanoparticles of hydroxyapatite synthesized with lecithin (nHAp-PC) was studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system. We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles. Product exhibits crystalline structure and chemical composition of hydroxyapatite, with visible traces of lecithin. Difference in surfactant amounts results in changes in particles morphology and their average size.
Highlights
In current research, the calcium phosphate materials, including hydroxyapatite (HAp), gather a lot of attention
In light of currently used technologies described above, we propose a novel approach to the wet chemical precipitation method for synthesis of hydroxyapatite nanoparticles
Synthesis of HAp-PC nanoparticles nHAp-PC nanoparticles were synthesized by the wet chemical precipitation method, under atmospheric pressure, with calcium nitrate (Ca(NO3)2·4H2O) as calcium source and diammonium phosphate ((NH4)2HPO4) as phosphorous source and lecithin as an additive to control product properties. (NH4)2HPO4, Ca(NO3)2·4H2O were dissolved in demineralized water, while lecithin was suspended
Summary
The goal of this paper is to describe the wet chemical precipitation process based on the application of solution of lecithin—zwitterionic surfactant, mixture of phosphatidylcholines (PC) ubiquitous in cellular membranes—as a controlling agent of product properties
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