Abstract
Learning through Silence: Amping up Cognition after Neonatal Hypoxic Seizures through AMPA Receptor Inhibition
Highlights
Hypoxia-Induced Neonatal Seizures Diminish Silent Synapses and Long-Term Potentiation in Hippocampal CA1 Neurons
Prior studies have highlighted the role of AMPA receptors in the pathogenesis of cognitive dysfunction and proepileptogenic diathesis of rats subjected to neonatal hypoxic seizures [3, 4]
Epilepsy Currents, Vol 12, No 5 (September/October) 2012 pp. 167–169 © American Epilepsy Society days prevents the appearance of cognitive impairment and seizure susceptibility following hypoxia. Even though these results provided a strong case for the pathogenic role of AMPA receptors in the early stages of this model, little was known about the molecular and pathophysiological changes during the period of cognitive impairment
Summary
Hypoxia-Induced Neonatal Seizures Diminish Silent Synapses and Long-Term Potentiation in Hippocampal CA1 Neurons. Prior studies have highlighted the role of AMPA receptors in the pathogenesis of cognitive dysfunction and proepileptogenic diathesis of rats subjected to neonatal hypoxic seizures [3, 4].
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