Abstract
Local field potential oscillations reflect temporally coordinated neuronal ensembles-coupling distant brain regions, gating processing windows, and providing a reference for spike timing-based codes. In phase amplitude coupling (PAC), the amplitude of the envelope of a faster oscillation is larger within a phase window of a slower carrier wave. Here, we characterized PAC, and the related theta phase-referenced high gamma and beta power (PRP), in the olfactory bulb of mice learning to discriminate odorants. PAC changes throughout learning, and odorant-elicited changes in PRP increase for rewarded and decrease for unrewarded odorants. Contextual odorant identity (is the odorant rewarded?) can be decoded from peak PRP in animals proficient in odorant discrimination, but not in naïve mice. As the animal learns to discriminate the odorants the dimensionality of PRP decreases. Therefore, modulation of phase-referenced chunking of information in the course of learning plays a role in early sensory processing in olfaction.
Highlights
Animals must modulate early sensory processing to optimize navigation of their environment (Gire et al, 2013a; Pakan et al, 2018)
We found similar differences in dimensionality between Exp1 and Exp2 for theta/beta phase-referenced high gamma and beta power (PRP) local field potential (LFP), but in this case there was no difference between peak and trough dimensionality (Figure 7-figure supplement 1 Aii, generalized linear model (GLM) p value < 0.001 for Exp1 vs. Exp2 and >0.05 for peak vs. trough, 379 d.f.)
We asked whether information carried by high frequency oscillations in brain regions involved in early sensory processing changes when observed at different phases of theta frequency oscillations
Summary
Animals must modulate early sensory processing to optimize navigation of their environment (Gire et al, 2013a; Pakan et al, 2018). This experience-dependent shaping involves an interplay between sensory input, behavioral state, arousal and motor activity. Oscillations, carries distinct information at different phases of each cycle (Jensen, 2001; Kepecs et al, 2006; Lisman and Jensen, 2013). Place cell preferred fields are encoded temporally through phase precession in relation to hippocampal theta oscillations (Buzsaki and Draguhn, 2004; Lisman, 2005; O'Keefe and Recce, 1993; Skaggs et al, 1996).
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