Abstract
As a result of learning from wisdom of the ecosystem, a novel control method exploiting microbial interaction in co-culture system was developed. In order to control pH in an antimicrobial peptide (nisin) production process by Lactococcus lactis subspecies lactis (ATCC11454), microbial interaction betweenlactate production by L. lactis and its assimilation by Kluyveromyces marxianus was utilized. A cascade pH controller coupled with DO control was newly developed and the specific lactate consumption rate of K. marxianus was controlled by changing the dissolved oxygen (DO) concentration. pH and lactate were kept at constant levels and nisin accumulated in the medium to a high level, compared with other pH control strategies such as processes without pH control and with pH control by addition of alkali. Stability of this control system with disturbance of inoculum sizes of both microorganisms wasinvestigated as well.
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