Abstract
Predicting ancestral sequences of protein kinases reveals the molecular details that underlie different modes of activation.
Highlights
Related research article Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gu€mu€s ZH, Holt LJ. 2019
One way to do this is to study biological entities that have become extinct, as this can provide insights into the form and function of their present-day descendants. This is perhaps best exemplified by paleogenetics and paleoproteomics research, where DNA and protein molecules from ancient biological samples are extracted and sequenced to help us better understand the evolutionary relationships between different species
Many large gene and protein families have evolved through rounds of gene duplication and functional specialization over hundreds of millions of years, which puts them beyond the reach of paleogenetics and paleoproteomics
Summary
Related research article Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gu€mu€s ZH, Holt LJ. 2019. This is perhaps best exemplified by paleogenetics and paleoproteomics research, where DNA and protein molecules from ancient biological samples are extracted and sequenced to help us better understand the evolutionary relationships between different species. One approach, called ancestral sequence reconstruction, involves using a statistical model to analyze the sequences of closely-related proteins from different organisms and generate plausible sequences for their ancestors (Hochberg and Thornton, 2017).
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