Abstract
The lysosomal carboxypeptidase, cathepsin A (protective protein), stabilized β-galactosidase and activates neuraminidase by forming a high-molecular-weight complex with them, but is also able to hydrolyse in vitro a number of bioactive peptides. We specifically inhibited endogenous serum cathepsin A in rats by immunizing the animals with human cathepsin A. Immunization was associated with long-term suppression of the learning ability of rats in an active avoidance test and motor and exploratory activities in an open field test. These results suggest the involvement of cathepsin A in the metabolism of peptides implicated in memory consolidation. Immunization did not affect blood pressure and heart rate regulation, which is in contrast with an earlier suggestion that cathepsin A has a role in the inactivation of endothelin and in the generation of angiotensin II. © 1997 John Wiley & Sons, Ltd.
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