Abstract
Aims To investigate the association between GFR and body composition in healthy young men with differing body mass. Methods Three age-matched groups were recruited: normal BMI (n = 22) 30 kg/m2 and BIA body fat ≤20%, and obese (n = 22) with BMI ≥30 kg/m2 and BIA body fat > 30%. Dietary analyses, GFR by clearance of 99mTc-DTPA, and body composition by dual-energy X-ray absorptiometry (DEXA) were measured in all participants. Results Muscular men had higher GFR (mean 186.4 mL/min; 95% CI 171.7–201.1) than normal BMI and obese groups (p = 0.0007). Fat mass protein intake, and smoking status were not associated with GFR; whereas lean mass had the strongest association with GFR. In all subgroups, skeletal muscle mass correlated significantly with GFR (p = 0.04). In multi-variate models, variables with the strongest associations with GFR were age (p = 0.0009) and lean mass (p = 0.0001). Conclusions Age and lean mass were strong determinants of GFR in healthy men of various body compositions. We estimate that GFR decreases by 1 mL/min/year of age and increases 2.3 mL/min/kg of lean mass in healthy men.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
