Abstract
Ancient civilization to present-day cultural and technological development, human over the world has been using plants as a source of natural medicine for their basic needs. Clerodendrum serratum (Linn.) Moonis one such traditionally well-accepted plant used vigorously in Indian ayurvedic therapeutic purposes. Despite its ethnomedicinal significance, the neuroprotective prospects and relevance of Clerodendrum serratum (CSL) remain unaddressed. Therefore, in the present study, we explored several in-vivo antioxidant enzymatic assays followed by acetylcholinesterase enzyme (AChE) inhibitory activity against neurodegenerative disorders (NDs) in mice model and explore the beneficial impact of the plant extract. Furthermore, the in-silico molecular docking approach was employed to evaluate the inhibitory potential of the plant-derived bioactive compounds against the imperative proteins associated with neurodegenerative disorders. The plant extract showed promising results in all in-vivo enzymatic assays indicating its positive role over several neurodegenerative disseases namely, Alzheimer’s and Parkinson’s disease. The histological and in-silico investigation also reveled this plant extract is promising in elevating neurodegenerative disorders. Therefore, it seems likely that this plant can be used as an anti-cognitive agent for future drug development.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
