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Abstract
The effect of 1, 3, 5, and 20 mumol/L lead on normal red cell sodium-lithium countertransport was studied in vitro. Red cell suspensions incubated with lead had increased sodium-lithium countertransport at all concentration levels compared with paired, unleaded controls when all groups were evaluated by analysis of covariance (F = 19.2, P less than 0.001). The effect of lead was concentration dependent (r = 0.998, P less than 0.001). These observations suggest that abnormalities in sodium transport are involved in the pathogenesis of lead-induced hypertension. Because increased red cell sodium-lithium countertransport is characteristic of essential hypertension, these observations further suggest that lead-induced and essential hypertension may share common pathophysiological mechanisms.
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Schedule a callMore From: American journal of kidney diseases : the official journal of the National Kidney Foundation
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