Abstract
This brief report presents a practical approach to the diagnosis of the main coagulopathies in children with haemorrhagic manifestations. It discusses the clinical-anamnestic elements that should suggest further laboratory investigations. Then, after a brief review of coagulation physiology and main coagulation tests, three clinical scenarios based on PT and aPTT results are described. In particular, the paper focuses on the two most common congenital coagulopathies: haemophilia and von Willebrand disease. Recently, a new drug, emicizumab, has been introduced in the prophylaxis of severe haemophilia A, with great benefits on patients’ quality of life.
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