Abstract

Le Dr Joseph Applebe Gilchrist (1893–1951), diabétique depuis 1917, s’est prêté en décembre 1921, dans le plus grand secret, au premier essai clinique de l’extrait de pancréas mis au point par son ami Frederik Banting avec Charles Best. Malheureusement, l’extrait administré par voie orale s’est avéré inefficace. Gilchrist dut attendre février 1922 pour recevoir par voie intramusculaire un extrait actif. Il devint ainsi le deuxième diabétique à bénéficier de l’insuline, après Leonard Thomson. Il orienta sa carrière vers la diabétologie. Par la suite, il participa à la standardisation de l’insuline de qualité en payant de sa personne au point de gagner le surnom de « human rabbit ». Puis, il exerça comme diabétologue libéral à Toronto (Canada). Dr. Joseph Applebe Gilchrist (1893–1951), diabetic since 1917, secretly took part in the first clinical trial of the pancreatic extract developed by his friend Frederik Banting in collaboration with Charles Best in December 1921. Unfortunately, the extract administered orally was found to be ineffective. Gilchrist had to wait until February 1922 to receive an intramuscular active extract. Then, he became the second person with diabetes to benefit from insulin, after Leonard Thomson. He was involved in the development and in the standardization of insulin by experimenting on himself to such an extent that he was nicknamed the “human rabbit”. Then, he moved his career to diabetology and practiced as a private diabetologist in Toronto (Canada).

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