Abstract
The eminent scientists who examined Vacher's brain did not discover evidence of any brain disease known at that time. The results of the histological tests which revealed numerous corporea amylacea, which were not hitherto taken into account, suggest various hypothesis; in order of likehood: the role of cerebral-meningeal lesions, a temporal lobe epilepsy, a familial neurodegenerative disease, such as a polyglucosan body disease. These diagnostic formulations, which propose an organic lesion underlying Vacher's troubles, would support those who argued in favour of his insanity.
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