Abstract
Introduction and aim: Coronary artery disease (CAD) is a multifactorial condition caused by the interplay of hereditary and environmental factors. The major objective of this research is to evaluate the Low-density of lipoprotein receptor (LDLR) single nucleotide polymorphisms (SNPs) rs688 and rs5925 and the lipid profile in coronary artery disease (CAD) and their connection with CAD. Materials and methods: The research included 50 patients with coronary artery disease and 30 healthy controls. To examine the lipid profile parameters, fasting venous blood was taken. Genomic DNA was isolated, amplified, and identified using an allele-specific polymerized chain reaction for the genetic study of LDLR SNPs. Results: Lipid profile parameters were shown to be substantially (p0.000) linked with coronary artery disease. There was, however, no significant change in the allele and genotype frequencies of the LDLR SNPs rs688 and rs5925 between the case and control groups investigated. Conclusion: The current investigation was unable to detect a significant connection between the LDLR gene SNPs rs688 and rs5925 with CAD.
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