Abstract
BackgroundLow density lipoprotein –Cholesterol (LDL-C) is one of the main factors for assessment of cardiovascular disease risk and it is more important in diabetic patients. Various methods are currently used for LDL-C measurements which are compared in this study.MethodsThis study was conducted in Diabetes Research Center based on laboratory results of 1721 diabetic patients who referred to laboratory for regular follow-up of lipid profile. LDL-C was measured directly and also estimated according to Friedwald, Anandraja and Chen formulas.ResultsResults of direct LDL-C measurements were lower than all calculations at triglycerides (TG) levels less than 150 mg/dL while in higher TG levels direct measurement values were higher than Friedwald and Anandraja formula. Friedwald and Chen formula results had better correlation(r) with direct measurement than Anandraja in different levels of TG and also were able to define LDL-C > 100 mg/dL more accurately.ConclusionsAlthough we observed excellent correlation between the studied formulas with direct measurement, using the formula can misclassified diabetic patients with LDL-C values near threshold (100 mg/dL). However calculated LDL-C based on Chen and Friedwald formula can be a suitable alternative for direct measurement especially in regions with limited resources.
Highlights
Low density lipoprotein –Cholesterol (LDL-C) is one of the main factors for assessment of cardiovascular disease risk and it is more important in diabetic patients
We evaluated the results of lipid profile of 1721 patients with type 2 diabetes
Results of direct measurement of LDL-C were lower than all calculations in the group of patients with TG level less than 150 mg/dL
Summary
Low density lipoprotein –Cholesterol (LDL-C) is one of the main factors for assessment of cardiovascular disease risk and it is more important in diabetic patients. The number of diabetic people is increasing due to population growth and high prevalence of physical inactivity and obesity. The global prevalence of diabetes in adults is estimated to increase from 8.8% in 2015 to 10.4% in 2040 [3] as a major health problem. Cardiovascular diseases (CVD) are among the main comorbid conditions associated with diabetes, which causes about 70% of deaths in diabetics aged more than 65 years [9]. Due to this high rate of mortality, CVD risk
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