Abstract
Background: Organophosphorus compounds have been widely used for a few decades in agriculture for crop protection and pest control. In India Organophosphorus poisoning is the most common. The objective of our study was to measure the LDH Level in acute organophosphorus poisoning
 Methods: This study was conducted among minimum 100 patients acute organophosphorus poisoning admitted in Casualty ward, MICU and attending medical ward of JLN hospital, Ajmer during Aug 2018 to July 2020. Serum lactate dehydrogenase estimation by spectrophotometric analysis using Beckman Coalter AU 680
 Results: These were significantly higher among deaths on day 1 and 3(810±372.99 and 1027.09±458.26, respectively) in comparison to survivors on day 1 and 3 (538.18±300.42 and 365.19±175.49, respectively). Significant difference was found between mean values of different levels of severity of LDH on day 1 and 3.
 Conclusion: In conclusion, this study found that Serum LDH can be used as biomarker in diagnosis or stratifying severity of acute OP poisoning, as it is cheap and easily available, especially in developing countries. Serial measurements of serum LDH levels in acute OP poisoning can predict the prognosis.
 Keywords: LDH, OP poisoning, Severity
Highlights
Organophosphorus [OP] compounds have been widely used for a few decades in agriculture for crop protection and pest control
Significant difference was found between mean values of different levels of severity of lactate dehydrogenase (LDH) on day 1 and 3
In conclusion, this study found that Serum LDH can be used as biomarker in diagnosis or stratifying severity of acute OP poisoning, as it is cheap and available, especially in developing countries
Summary
Organophosphorus [OP] compounds have been widely used for a few decades in agriculture for crop protection and pest control. Some OP esters are still used to treat glaucoma [Ecothiopate] In addition to these beneficial agricultural, veterinary, and medical uses, some highly potent OP anticholinesterase compounds, including tabun, sarin and soman, have been used as “nerve gases” in chemical warfare. They are been used as plasticizers, stabilizers in lubricating and hydraulic oils, flame retardants, and gasoline additives.[1]. Elevations are seen in Serum lactate dehydrogenase (LDH) and creatine kinase (CK) activities following acute OP poisoning as a result of muscle injury. Serial measurements of serum LDH levels in acute OP poisoning can predict the prognosis.
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