Abstract
We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open access web resource—the Lung Cancer Explorer (LCE), which enables researchers and clinicians to explore these data and perform analyses. Users can perform meta-analyses on LCE to gain a quick overview of the results on tumor vs non-malignant tissue (normal) differential gene expression and expression-survival association. Individual dataset-based survival analysis, comparative analysis, and correlation analysis are also provided with flexible options to allow for customized analyses from the user.
Highlights
Supplementary material The online version of this article contains supplementary material, which is available to authorized users.Lung cancer is the leading cause of cancer-related death worldwide
We describe our development of a new data commons, Lung Cancer Explorer (LCE) with a web application, populated by a centralized lung cancer database
“All Cancers”, “Adenocarcinoma” (ADC), or “Squamous Cell Carcinoma” (SCC), to allow users to choose the lung cancer subtype(s) they want to include in the meta-analysis since the survival association and expression difference between tumor and normal could be cancer-type specific
Summary
Lung cancer is the leading cause of cancer-related death worldwide. Despite tremendous efforts put toward diagnosis and treatment, the five-year survival rate of lung cancer is still as low as 18% [1]. Over the past few decades, advancements in genome profiling techniques have greatly improved our understanding of cancer development at the Center, 2500N State St, Jackson, MS 39216, USA. Simmons Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.
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