Abstract
8025 Background: Fatigue is highly prevalent in the cancer population and nutritional factors are among the postulated causes. Deficiency of the micronutrient L-carnitine could play a role by reducing energy production through fatty acid oxidation. We are presenting preliminary data of an open-label, dose-finding study to determine safety of one week L-carnitine supplementation in cancer patients with fatigue and carnitine deficiency. Methods: Patients with cancer, fatigue and carnitine deficiency, >18 years, Karnofsky score >50, and at least one week after completion of chemotherapy, were accrued. Carnitine deficiency= free carnitine 0.4. A standard up-down dose finding design was utilized to determine the MTD of L-carnitine given by mouth. The beginning dose was 250 mg/day; doses were increased by 500 mg up to 3000 mg/day. Three patients were enrolled at each dose level. Fatigue (BFI), depressed mood (CES-D), quali...
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