Abstract
53BP1 is a scaffold protein involved in Poly-ADP Ribose Polymerase inhibitor (PARPi) hypersensitivity in BRCA1 negative cancers. 53BP1 foci accumulate at DNA double strand breaks and protect them from end resection, favoring nonhomologous end joining for repair. 53BP1 has an oligomerization domain and two LC8 binding sites that are necessary for ideal focus formation. LC8 is a small dimeric protein that binds over 100 client proteins at intrinsically disordered regions (IDRs), leading to their dimerization.
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