Abstract

Anapa is the world’s first and unique disposable infusion device using self-produced CO2 as power source. By its unique design, it is safe of the many shortcomings of mechanical, electronic and elastomeric devices...

Highlights

  • Anapa is the world’s first and unique disposable infusion device using self-produced CO2 as power source

  • The stability-indicating method involves the use of LC-MS/MS analysis allowing an unambiguous assessment of drug purity, stability and compatibility with medical devices [3,4]

  • The samples were taken over the studied period and submitted to LC-MS/MS analysis allowing an unambiguous assessment of drug purity, stability and compatibility

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Summary

Introduction

Anapa is the world’s first and unique disposable infusion device using self-produced CO2 as power source. It is safe of the many shortcomings of mechanical, electronic and elastomeric devices It offers the best combination of accuracy, safety and convenience in pain palliation. In this medical device, drug stability evaluation is needed to verify the compatibility of polycarbonate surface of Anapa’s body with several drugs handled in hospitals. Oxycodone is an analgesic drug belonging morphine derivatives and it is employed frequently to manage cancer pain since with respect to morphine displays minor side effects. The aim of this report is to study the stability of Oxycodone Hydrochloride in Anapa Anaplus disposable pump in Normal Saline (NS), at storage periods and temperatures similar to those the drug is usually prepared and stored in Pharmacies and Hospitals for administration to patients [2]. The stability-indicating method involves the use of LC-MS/MS analysis allowing an unambiguous assessment of drug purity, stability and compatibility with medical devices [3,4]

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