Abstract
A simple, rapid and precise LC method has been developed to determine the total concentrations of cefotiam (reported protein-binding ratios of 40–62%) in human serum. New procedures were incorporated in which proteins denatured by acetonitrile were dissociated from cefotiam. Macromolecular impurities above 30 kDa were entirely removed using an ultrafiltration membrane. The assay can be applied to therapeutic drug monitoring of cefotiam in serum and to pharmacokinetic studies in patients.
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