Abstract
A new method has been developed to determine clonidine hydrochloride in Zhenju Jiangya Tablets using ion-pair HPLC coupled with neutral column chromatography in this paper. Clonidine hydrochloride is an active component and occurs in very low amounts. The sample was purified by neutral Al2O3 column chromatography instead of liquid–liquid extraction and measured by reversed phase ion-pair chromatography with 1-heptanesulfonate at acidic pH with UV-detection. Result showed that clonidine hydrochloride had good linearity in the range of 1.1–11.0 μg mL−1 (r = 0.9993) and the average recoveries were 96.5–99.3% (RSD 2.1–4.8%).
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