LBODP045 Correlation Of Acetone Breathing Level In Serum Ketone Bodies Level Of Diabetes Ketoacidosis By Non-invasive Acetone Gas Analysis Device (g-breath) Multicenter Study

Abstract

Abstract Background Diagnosis of ketosis associated with DKA can be difficult due to variability in the metabolic state of DKA patients beta–hydroxybutyrate (BHB) are the main forms of ketone and followed by acetoacetic acid (AcAc) and acetone. Objective Find the correlation between breath acetone and serum BHB, AcAc and acetone during treatment duration of DKA. Materials and Methods We use metal Oxide Semiconductor (MOS) methods called G-Breath for measurement of exhaled acetone compared with serum BHB, AcAc and acetone level during treatment of DKA, in patients with hyperglycemia and suspected DKA. Exhaled acetone concentration will be represent as two electrical signal parameters breath acetone breath (ppmv) and total volatile organic compound (VOC). Results Serum parameters to diagnostic DKA especially ketone metabolites were significant higher in DKA group when compared with hyperglycemic group; serum acetone in DKA group was 67.65±79.52 vs 4.20±4.12 mg/L in hyperglycemic group by p value=0. 004, serum BHB in DKA group was11.19±12.96 vs 1.73±1.34 mg/dL in hyperglycemic group by p value=0. 007, serum AcAc was 31.90±16.98 vs 5.87±7.58 µg/mL in hyperglycemic group by p value<0. 001. In breath analytic parameters we found acetone in breath was significant higher DKA group 5.20±1.34 vs 1.18±1.77 in hyperglycemic group with p-value 0. 040. The correlation study acetone in breath was significant to all ketone metabolite of DKA such as serum acetone, The cut of point, sensitivity, specificity and Area under the Curve (AUC) we found serum acetone was the best test for diagnosis DKA with 100% sensitivity, 99.93% specificity AUC=0.987 with p<0. 001. The breath acetone for diagnosis of DKA at cut of point 2.15, sensitivity 100%, specificity 71.4% (AUC=0.847, p=0. 003) Conclusions: This study shown that acetone measurement in exhale with non-invasive device call G-breath can be used in part of DKA diagnosis with comfortable and can be warning diabetes for serious emergency condition. Keywords: Breath biomarkers, Breath acetone, Diabetic ketoacidosis, correlation Presentation: No date and time listed