LBA02-06 PSYCHO-SOCIAL DISTRESS AND QUALITY OF LIFE IN PATIENTS AFTER RADICAL CYSTECTOMY: ONE YEAR FOLLOW-UP IN 842 GERMAN PATIENTS

Abstract

You have accessJournal of UrologyCME1 Apr 2023LBA02-06 PSYCHO-SOCIAL DISTRESS AND QUALITY OF LIFE IN PATIENTS AFTER RADICAL CYSTECTOMY: ONE YEAR FOLLOW-UP IN 842 GERMAN PATIENTS Henning Bahlburg, Karl Tully, Florian Roghmann, Joachim Noldus, and Guido Mueller Henning BahlburgHenning Bahlburg More articles by this author , Karl TullyKarl Tully More articles by this author , Florian RoghmannFlorian Roghmann More articles by this author , Joachim NoldusJoachim Noldus More articles by this author , and Guido MuellerGuido Mueller More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003361.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: As both screening and treatment of patients with muscle-invasive bladder cancer improve, the rate of cancer survivors will increase. Therefore, long term medical, psychological and social effects should be investigated. This study aims to investigate psycho-social distress and quality of life in German patients after radical cystectomy (RC). METHODS: This study relied on prospectively collected data for patients, who underwent three weeks of inpatient rehabilitation after RC between April 2018 and December 2019. Data on psycho-social distress and quality of life were collected 4 weeks (T1), 6 months (T2) and 12 months (T3) post-surgery by validated instruments (QLQ-C30, QLQ-BLM, QSC-R10). Uni- and multivariate logistic regression was performed to identify predictors for high psycho-social distress. RESULTS: 842 patients (683 male, 159 female) were included. 447 patients (326 male, 121 female) received an IC, 395 (357 male, 38 female; p<0.001) received an INB. Tumor stage ≥pT3a (41.4% vs 24.1%; p<0.001) and lymph node metastases (19.9% vs 11.8%; p<0.001) were significantly more often present in patients with an IC. Health related quality of life (HRQoL) did not differ between the cohorts and steadily improved during follow-up. At T2, social, emotional and cognitive function as well as future worries and body image worsened in patients only to improve again at T3 in all patients, but especially in patients with an INB. Overall, 34.9% of all patients reported high psycho-social distress (QSC-R10 ≥15) at T1. During follow-up, no significant difference in psychosocial distress between both cohorts was observed. However, at both T2 and T3, over 40% of all patients still reported high psycho-social distress. Univariate regression analysis identified lymph node metastases as a predictor for high psycho-social distress at T3 (OR 2,123; CI 1,194–3,777; p=0,010). Multivariate regression analysis revealed both age ≤ 59 (OR 1,731; CI 1,056–2,838; p=0,030) and lymph node metastases (OR 2,073; CI 1,133–3,793; p=0,018) as predictors for high psycho-social distress at T3. CONCLUSIONS: Overall, HRQoL improves in all patients one year after RC. However, some sub-scales such as future worries, role function and emotional function still bother patients to varying degrees. A significant portion of both patients with an IC and an INB suffer from high psychosocial distress one year after RC. Especially young patients with lymph node metastases should be monitored regularly and undergo psychological counselling if necessary. Source of Funding: This study was funded by the “Nordrhein-Westfalen Association for the Fight Against Cancer, Germany.” The funder had no influence on the study design, data collection and analysis or preparation of the abstract. © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1188 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Henning Bahlburg More articles by this author Karl Tully More articles by this author Florian Roghmann More articles by this author Joachim Noldus More articles by this author Guido Mueller More articles by this author Expand All Advertisement PDF downloadLoading ...