LBA SO-34 Impact of BRAF-V600E mutation on immunologic characteristics of the tumor microenvironment (TME) and associated genomic alterations in patients with microsatellite instability-high (MSI-H) or mismatch-repair–deficient (dMMR) colorectal cancer (CRC)

M Salem,S Kopetz,S El-Refai,J Tabernero,F Sinicrope,J Tie,T George,E Van Cutsem,E Mauer,S Lonardi,T André,M Overman,D Foureau

doi:10.1016/j.annonc.2022.04.441

LBA SO-34 Impact of BRAF-V600E mutation on immunologic characteristics of the tumor microenvironment (TME) and associated genomic alterations in patients with microsatellite instability-high (MSI-H) or mismatch-repair–deficient (dMMR) colorectal cancer (CRC)

M Salem, S Kopetz + Show 11 more

https://doi.org/10.1016/j.annonc.2022.04.441

Copy DOI

Journal: Annals of oncology : official journal of the European Society for Medical Oncology	Publication Date: Jun 1, 2022
Citations: 2

Affiliation: Levine Cancer Institute, The University of Texas MD Anderson Cancer Center, Tempus Labs (United States), Vall d'Hebron Institute of Oncology, Mayo Clinic, Winneshiek Medical Center, Peter MacCallum Cancer Centre, University of Florida, KU Leuven, Istituto Oncologico Veneto, Istituti di Ricovero e Cura a Carattere Scientifico, Sorbonne Université, Hôpital Saint-Antoine

#BRAF V600E Mutation #Genomic Alterations In Patients + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

The BRAF V600E mutation is associated with the hypermethylator phenotype CIMP, which can also lead to the MSI-H phenotype. BRAF V600E mutation and MSI-H/dMMR status seem to be biologically intertwined; however, the impact of coexisting BRAFV 600E mutations on the TME and immunometabolomic features of MSI-H/dMMR CRC tumors is not well characterized.

Full Text