Abstract
Monophosphoryl lipid A (MPLA) is a low-toxicity derivative of LPS with immunomodulating properties. Nanoparticle (NP) encapsulation of immunomodulatory agents may allow for effective delivery to tumor sites as well as tumor draining lymph nodes (TDLN) and stimulation of anti-tumor immune responses while minimizing systemic side effects. Our bioadhesive NP (BNP) platform has been used for delivery of chemotherapy drugs with enhanced efficacy in pre-clinical models of solid tumors including SCC. To evaluate the cellular association and retention of BNP in TDLN, we used flow cytometry to assess immune cell uptake after in-vivo intratumoral (i.t.) delivery of Cy5-BNP to established PDVC57 SCC tumors.
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