Abstract
Mast cells (MCs) are tissue-resident immune cells, which play a pivotal role in skin hypersensitivity reactions. MCs activation via Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) is independent of the classical IgE-mediated pathway, which gained much interest recently. Calcium mobilization is crucial to mast cell activation and functional regulation. Ryanodine receptor (RYR) expresses on the sarcoplasmic reticulum and regulates intracellular calcium liberation. Although MRGPRX2 activation induces boosted intracellular calcium levels, the role of RYR in MRGPRX2 mediated MC activation has not been fully addressed.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
