LB977 NK cells in the pathogenesis of hidradenitis suppurativa (HS)

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with deep-seated lesions in the apocrine gland areas of the body. Recruitment and activation of innate and adaptive immune cells around hair follicles drive initiation and progression of HS; however, the nature of the cell populations and underlying mechanisms remain unclear. scRNAseq revealed that NK cells and CD4 T cells were major lymphocyte populations in HS. Confocal microscopy showed that HS, but not normal skin, contained elevated numbers of CD56dim and CD3+CD56bright NK cells.