Abstract
Pyoderma gangrenosum (PG) is a debilitating skin condition characterized by deep, pus-filled, non-healing ulcers packed with neutrophils and is a common extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Strikingly, ∼40% of people with an initial presentation of PG go on to be also diagnosed with IBD, suggesting common factors drive the pathogenesis of these diseases. The molecular and cellular mechanisms of PG and IBD co-development are currently unknown. Impeding the development of effective treatments for these individuals is the absence of an animal model that exhibits features of both diseases.
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