Abstract
In vitro skin permeation testing (IVPT) is often used to ensure sufficient efficacy of dermaceuticals. IVPT studies utilize viable tissue membrane to represent in vivo conditions. The intact barrier of such tissue membrane provides biological relevance, in vitro. Transepidermal water loss (TEWL) measures changes in water vapor density on the skin surface. The purpose of this study was to evaluate TEWL as an appropriate barrier integrity test, in vitro, and determine an acceptable range using a Delfin® Vapometer.
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