Abstract
Zinc is a trace element that requires for more than 2000 transcription factors. Thus, zinc could have functions in development, differentiation, and cell growth of many cell types including cancer cells. Prior studies reported that zinc induced apoptosis in cancer cells, such as glioma, bladder, prostate, breast, and melanoma. Topical application of high concentration zinc containing Mohs paste is effective to shrink skin cancers including squamous cell carcinoma (SCC), breast cancer. However, the evidences of direct effect of zinc in growth and cell migration of cutaneous SCC cells are scarce.
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