Abstract
Psoriasis is an immune-mediated inflammatory skin disease that affects large proportions of populations worldwide. As the key sentinel immune cells, mast cell activation is involved in the early onset of psoriasis. SBSN, a secretory protein processed by stratum spinous of stratified epithelium, regulates epidermal differentiation and skin barrier under physiological conditions. The expression of SBSN is significantly increased in the psoriatic lesions. However, whether it could play a pro-inflammatory role in psoriasis by activating mast cells is unclear.
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