Abstract
ATR (Ataxia telangiectasia and Rad3-related kinase) ensures completion of DNA replication prior to mitosis and its inhibition is known to sensitize cancer cells to DNA damage. Excitingly, with the recent availability of potent, selective ATR inhibitors (ATRi), multiple studies indicate that ATR inhibition can potentiate anti-tumor immunity, largely through unknown mechanisms that may induce cGAS/STING/interferon. Here we explore if ATR inhibition could target Merkel cell carcinoma (MCC) which is immunogenic but often becomes refractory to PD-1 pathway blockade.
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