Abstract

Therapy of cutaneous squamous cell carcinoma (cSCC) is a big challenge when it progresses into invasive cSCC which involves a deep range with a high degree of malignancy. Photodynamic therapy is a promising method utilized in tumor therapy while its applications are limited due to the low penetration depth of light in tissues and weak efficacy of each single treatment. Herein, a novel nanoplatform of X ray responsive, photosensitizer and immunologic adjuvant imiquimod loaded nano-scintillator (ScMMI) mediated triad photodynamic therapy (X-IPDT) was constructed to accomplish the inhibition of cSCC growth, benefiting from the deep penetration ability of X ray and simultaneous enhanced immunological effect.

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