Abstract
The Purpose of the study was to evaluate a model drug for topical application using various invitro screening models; skin barrier, invitro skin irritation and invitro skin permeation testing. The skin barrier function assessment was performed by Trans Epithelial Water Loss (TEWL) measurements. The skin irritation potential was assessed using the EpiDerm® in vitro model in which tissue viability was determined using the MTT conversion assay. The IVPT study was performed across dermatomed human fresh frozen skin using Franz type diffusion cells and drug content was analyzed using LCMS/MS.
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