Abstract
Treatment of melanoma (MSC) and non-melanoma skin cancers (NMSCs, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC)), affecting one-fifth of the US population, is hampered by drug resistance, side effects, and low bioavailability. Owing to low molecular weight and the ability to enter cells, small molecules are gaining ground towards enhancing bioavailability and minimizing some of the side effects associated with classical cancer drugs. Herein, we synthesized a mini-library of 86 compounds via C-N/C-C coupling, direct substitution on the aromatic ring, or a modified Skraup–Doebner–von Miller approach, and their solubility and biological properties were characterized.
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