Abstract
Calciphylaxis is a vasculopathy characterized by calcium deposition in cutaneous vessels resulting in skin ulceration. Sodium thiosulfate (STS) has been used to treat calciphyaxis and can be administered via intravenous (IV) or intralesional (IL) injection. Retrospective chart review of patients treated for calciphylaxis at a tertiary hospital was conducted. Skin lesions were followed for at least two years following STS treatment initiation for three outcomes: 1) clinical improvement defined by reduction in lesion size or halted progression of purpura; 2) resolution of disease activity characterized by resolution of purpura; and 3) healing of ulcers.
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