Abstract
Ascorbic acid (Vitamin C) is a potent antioxidant and is also suggested to affect genome activity via modifiable epigenomic processes as an enhancer of demethylases, consequently spatially and temporally altering gene expression. Utilizing ex-vivo skin models and standard RNA sequencing (NOVASEQTM/HISEQ), changes in gene expression within 24 h and 48h posttreatment were observed. Single, topical application of 10% buffered ascorbic acid (AA) altered skin’s transcriptional profile at both 24 and 48 hours post-treatment, with a total of 229 and 280 affected gene transcripts, respectively.
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