LB720 Mechanobiology and periorbital aging: Skin cell response to micromovements and their duration

Abstract

Periorbital skin is more vulnerable than the surrounding facial skin since it is much thinner and not have the same appendages as the rest of the face. Another unique characteristic is that it is under constant movement due to daily blinking, and facial expressions including smiling, laughing and crying. As a result, periorbital skin cells are under constant change of mechanical stress with continuous stretching and release. The cells sense the strain (deformation) in the extracellular matrix (ECM) caused by mechanical stresses and, through mechanotransduction, convert this information into very specific cellular responses.